Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus
نویسندگان
چکیده
منابع مشابه
Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus
A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy. In 2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of MCC. It is found clonally integrated into the majority of MCC tumours, which require MCPyV oncoproteins to survive. Since its...
متن کاملDistinct Merkel Cell Polyomavirus Molecular Features in Tumour and Non Tumour Specimens from Patients with Merkel Cell Carcinoma
Merkel Cell Polyomavirus (MCPyV) is associated with Merkel Cell carcinoma (MCC), a rare, aggressive skin cancer with neuroendocrine features. The causal role of MCPyV is highly suggested by monoclonal integration of its genome and expression of the viral large T (LT) antigen in MCC cells. We investigated and characterized MCPyV molecular features in MCC, respiratory, urine and blood samples fro...
متن کاملSeroepidemiology and primary infections of the recently detected Merkel cell polyomavirus and trichodysplasia-spinulosa associated polyomavirus
................................................................................................................... 5 LIST OF ORIGINAL PUBLICATIONS ....................................................................... 7 ABBREVIATIONS ......................................................................................................... 8 INTRODUCTION ...........................................
متن کاملMerkel Cell Polyomavirus Strains in Patients with Merkel Cell Carcinoma
We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.
متن کاملNew insights into merkel cell carcinoma.
Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and immunophenotypically, MCC is defined by both neuroendocrine and epithelial differentiation. Recently, the Merkel cell polyomavirus has been ...
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ژورنال
عنوان ژورنال: Cancers
سال: 2014
ISSN: 2072-6694
DOI: 10.3390/cancers6031267